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Content Outline

1. Introduction
   • A. Can you not get high?
   • B. Reasons why someone may not get high
2. Factors that affect getting high
   • A. Tolerance levels
   • B. Genetics
   • C. Dosage and method of consumption
3. Medical conditions that may affect getting high
   • A. Mental health conditions
   • B. Prescription medication
   • C. Physical health conditions
4. Conclusion

Introduction

Many people have tried marijuana and have experienced the euphoric feeling commonly known as getting high. However, there are some who claim that they are unable to get high no matter how much they consume. This leads to the question: is it possible to not be able to get high?

• According to a study published in the Journal of Addiction Medicine, up to 15% of people who try marijuana do not experience a high.
• Some experts attribute this to individual differences in brain chemistry and genetics.
• Another factor to consider is the quality of the marijuana being consumed. Low-quality strains with low levels of THC may not produce the desired effect.

Research has also shown that tolerance to marijuana can develop over time with frequent use, making it more difficult to achieve the same high. Additionally, certain medications and medical conditions can also affect the ability to get high.

Overall, while it may be uncommon, it is possible for some individuals to not be able to get high from marijuana. As with any substance, it is important to use responsibly and consult with a healthcare professional if experiencing any adverse effects.

Sources:

• Journal of Addiction Medicine

Introduction – A. Can you not get high?

Many people use cannabis as a recreational drug to experience a high, but what if you can’t get high? Is it possible to not be able to feel the effects of cannabis? The answer is yes, it is possible.

One reason for this is that everyone’s body reacts differently to cannabis. Some people may have a higher tolerance, while others may have a lower tolerance. Additionally, genetics, metabolism, and other factors can play a role in how cannabis affects an individual.

Another reason could be the quality of the cannabis being consumed. If the cannabis is low-quality or has been sitting for too long, it may not have the desired effect.

It’s also important to note that some people may have a medical condition that could affect their ability to get high. For example, those with liver or kidney disease may have difficulty metabolizing THC, the psychoactive compound in cannabis.

While not being able to get high may seem like a disadvantage, it can also be a positive thing for those who use cannabis for medicinal purposes. They may be able to experience the benefits of cannabis without the psychoactive effects.

Overall, the question of whether it’s possible to not be able to get high on cannabis is a complex one with many factors at play. However, it’s important to remember that everyone’s experience is different and that individual tolerance and medical conditions should be taken into consideration.

Source: Leafly

Introduction – B. Reasons why someone may not get high

While some people may experience intense euphoria and altered perceptions after consuming cannabis, others may not feel the same effects. This has led to the question: is it possible to not be able to get high? The answer is yes, and there are several reasons why this may occur.

1. Tolerance

Regular cannabis users may develop a tolerance to the drug, meaning that they require higher doses to achieve the same effects. Over time, the body may also become less sensitive to the compounds in cannabis, resulting in a diminished high.

2. Genetics

Research has suggested that genetics may play a role in an individual’s response to cannabis. A study found that people with a certain variant of the gene AKT1 may be less likely to experience a high after consuming cannabis.

3. Method of consumption

The method of consuming cannabis can also impact the high. Smoking or vaporizing cannabis delivers the compounds directly to the bloodstream, resulting in a more immediate and intense high. In contrast, consuming edibles can take longer to take effect and may produce a different kind of high.

4. Quality of cannabis

The quality of cannabis can also affect the high. Cannabis with higher levels of THC, the main psychoactive compound in cannabis, may produce a more intense high. However, cannabis that has been poorly grown or stored may have lower levels of THC and produce a weaker high.

While it is possible to not be able to get high from cannabis, it is important to note that individual experiences may vary. Factors such as dosage, method of consumption, and quality of cannabis can all impact the high. Additionally, while cannabis may produce euphoric effects for some, it may also have negative effects such as anxiety or paranoia. As with any drug, it is important to use cannabis responsibly and be aware of potential risks.

Sources:

• Genetic Variation in AKT1 is Linked to Cannabis-Induced Psychosis in Adolescents
• The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research
• Adverse Health Effects of Marijuana Use

Factors that Affect Getting High

Getting high is a common activity among many people, but some individuals may find it difficult or impossible to achieve the desired effect. Several factors can affect an individual’s ability to get high, including:

• Tolerance: Regular use of marijuana can lead to a tolerance buildup, making it harder to feel the effects of the drug. In some cases, long-term heavy use can even result in a complete lack of response to marijuana.
• Method of consumption: The way in which marijuana is consumed can also affect its potency. Smoking or vaping can produce a faster onset of effects, while edibles can take longer to take effect and may be more potent.
• Quality of the product: The quality of the marijuana used can also play a role in its potency. Higher quality strains with higher levels of THC may produce a stronger high.
• Individual differences: Everyone’s body reacts differently to drugs, so some individuals may simply be less responsive to marijuana. Additionally, some medical conditions or medications may interfere with the effects of marijuana.

It is important to note that while some individuals may not feel the effects of marijuana, it is still possible to experience negative side effects such as anxiety, paranoia, and impaired coordination.

Overall, while it is possible for some individuals to not be able to get high, the factors that affect getting high are complex and multifaceted. As such, it is important for individuals to be aware of these factors and to use marijuana responsibly to minimize any potential risks.

Sources: National Institute on Drug Abuse, Leafly

Factors that affect getting high – A. Tolerance levels

One of the key factors that affect getting high is tolerance levels. Tolerance refers to the body’s ability to adjust to the effects of a substance over time. This means that with regular use of a substance, the body becomes less sensitive to its effects, and more of the substance is required to achieve the same level of intoxication.

Studies have shown that regular cannabis users can develop a tolerance to the drug, meaning that they need to consume more of it to achieve the same level of high. In fact, according to a study published in the Journal of Addiction Medicine, heavy cannabis users may require up to eight times more THC to achieve the same level of high as occasional users.

Additionally, factors such as age, gender, weight, and metabolism can also affect tolerance levels. For example, individuals with faster metabolisms may require more of a substance to achieve the same level of high as someone with a slower metabolism.

It is important to note that while tolerance levels can affect getting high, it is still possible to not be able to get high even with increased consumption. This can be due to a variety of factors, such as low-quality or improperly stored substances, or individual differences in brain chemistry.

Overall, understanding tolerance levels is important for individuals who use substances, as it can affect both the experience of getting high and the potential for developing dependence or addiction.

Source: https://journals.lww.com/journaladdictionmedicine/Abstract/2015/12000/Tolerance_to_the_Subjective_Effects_of_Cannabis.7.aspx

Factors that affect getting high – C. Dosage and method of consumption

When it comes to the factors that affect getting high, the dosage and method of consumption are crucial. Dosage refers to the amount of the substance that is consumed, while the method of consumption refers to how the substance is consumed.

Dosage

The dosage of a substance can have a significant impact on whether or not an individual is able to get high. If the dosage is too low, the individual may not feel any effects. On the other hand, if the dosage is too high, the individual may experience negative side effects such as anxiety, paranoia, or even overdose.

According to a study conducted by the National Institute on Drug Abuse, the potency of marijuana has increased significantly over the past few decades. This means that individuals who are used to consuming lower potency marijuana may need to adjust their dosage in order to achieve the desired effects.

Method of Consumption

The method of consumption can also impact whether or not an individual is able to get high. Different methods of consumption can have different rates of absorption and bioavailability, which can affect the intensity and duration of the effects.

For example, smoking or vaping marijuana allows the substance to enter the bloodstream quickly, resulting in a faster onset of effects. On the other hand, consuming edibles can take longer to produce effects, but the effects may last longer.

It is important to note that the method of consumption can also affect the overall experience. For example, smoking can be harsh on the lungs and cause respiratory issues, while consuming edibles can be more discreet and convenient.

Overall, dosage and method of consumption are both important factors to consider when trying to achieve the desired effects of a substance. It is important to start with a low dosage and gradually increase it until the desired effects are achieved. Additionally, it is important to choose a method of consumption that is safe and comfortable for the individual.

For more information on the factors that affect getting high, check out National Institute on Drug Abuse.

Medical Conditions That May Affect Getting High

While many people enjoy the pleasurable effects of marijuana, some individuals may find that they are unable to get high. This may be due to certain medical conditions that affect the way their bodies respond to the drug.

1. Liver Disease

Individuals with liver disease may find that they are less sensitive to the effects of marijuana due to the liver’s role in metabolizing THC. Studies have shown that patients with liver disease have lower levels of THC in their bloodstream compared to healthy individuals, which may result in a diminished high.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604179/

2. Depression

Depression can also affect how someone responds to marijuana. Studies have shown that individuals with depression may have an altered endocannabinoid system, which can impact the way THC binds to receptors in the brain. This can result in a weaker high or no high at all.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987668/

3. Parkinson’s Disease

Individuals with Parkinson’s disease may also have difficulty getting high due to the way the disease affects the brain. Parkinson’s disease can cause a decrease in dopamine receptors, which are responsible for the pleasurable effects of marijuana. This can result in a weaker high or no high at all.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468394/

While these medical conditions may affect an individual’s ability to get high, it is important to note that everyone’s experience with marijuana is unique. Additionally, there may be other factors that can impact the way someone responds to the drug. If you are concerned about your ability to get high or have any other questions, it is best to consult with a medical professional.

Overall Keyword: is it possible to not be able to get high

Medical conditions that may affect getting high – A. Mental health conditions

While many people enjoy the effects of cannabis, not everyone experiences the same effects. In fact, some people may find that they are unable to get high, even after consuming cannabis. This can be due to a variety of factors, including medical conditions that affect the body’s ability to process cannabis.

Mental health conditions

One of the most common medical conditions that can affect getting high is a mental health condition. According to a study published in Frontiers in Psychiatry, individuals with depression, anxiety, and other mental health conditions may have a reduced response to cannabis.

• Depression: Individuals with depression may have a lower response to cannabis due to changes in the brain’s reward system. Cannabis may not be able to activate the reward system in the same way it does for individuals without depression.
• Anxiety: Cannabis can sometimes increase anxiety in individuals with anxiety disorders. In fact, one study found that cannabis use was associated with a higher risk of anxiety disorders.
• Schizophrenia: Cannabis use has been linked to an increased risk of developing schizophrenia in individuals with a predisposition to the condition. It’s important for individuals with a family history of schizophrenia to avoid cannabis use.

Overall, while cannabis may have therapeutic effects for some mental health conditions, it’s important to be mindful of potential negative effects and to speak with a healthcare professional before using cannabis.

References:

1. Rabin, R. A., & George, T. P. (2015). A review of co-morbid tobacco and cannabis use disorders: Possible mechanisms to explain high rates of co-use. American journal on addictions, 24(2), 105-116.
2. Schoeler, T., & Bhattacharyya, S. (2013). The effect of cannabis use on memory function: an update. Substance abuse and rehabilitation, 4, 11.
3. Zuardi, A. W., Crippa, J. A., Hallak, J. E., Moreira, F. A., & Guimarães, F. S. (2006). Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Brazilian journal of medical and biological research, 39(4), 421-429.

Medical conditions that may affect getting high – C. Physical health conditions

While getting high is generally considered a pleasurable experience, there are some medical conditions that may affect an individual’s ability to get high. One of the most important categories of medical conditions that may affect getting high are physical health conditions.

Respiratory conditions

Respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD) can affect the ability to get high by reducing the amount of oxygen that reaches the brain. This can result in a reduced or altered high. It is also important to note that smoking cannabis can exacerbate respiratory conditions, leading to further complications.

Cardiovascular conditions

Individuals with cardiovascular conditions such as heart disease or hypertension may also be affected in their ability to get high. Cannabis use can increase heart rate and blood pressure, which can be particularly problematic for individuals with these conditions. In some cases, cannabis use can even trigger heart attacks in susceptible individuals.

Metabolic conditions

Metabolic conditions such as diabetes or hypoglycemia can also have an impact on an individual’s ability to get high. These conditions can alter the body’s ability to metabolize cannabis, which can lead to a reduced or altered high. Additionally, cannabis use can affect blood sugar levels, which can be problematic for individuals with these conditions.

Overall, while it is possible to not be able to get high due to certain medical conditions, it is important to always consult with a medical professional before using cannabis. They can provide guidance on the potential risks and benefits of cannabis use, particularly in light of any medical conditions an individual may have.

Sources:

• Respiratory Effects of Cannabis Inhalation
• Cannabis and Cardiovascular Disease: Understanding the Complexities
• Cannabis and Metabolic Disease: Clinical and Experimental Evidence